D26 Progressive multifocal leukoencephalopathy
Background and epidemiology Progressive multifocal leukoencephalopathy (PML) is a potentially fatal demyelinating disease caused by JC virus (JCV), a human double-stranded DNA virus of the polyoma family. Primary infection occurs during late childhood and the infection is usually asymptomatic. More than 85% of adults have detectable antibody to JCV indicating previous exposure. The virus remains […]